BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Lewis & Clark//NONSGML v1.0//EN BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:DAYLIGHT TZNAME:PDT DTSTART:20190310T100000 RDATE:20190310T100000 TZOFFSETFROM:-0800 TZOFFSETTO:-0700 END:DAYLIGHT END:VTIMEZONE BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:STANDARD TZNAME:PST DTSTART:20191103T090000 RDATE:20191103T090000 TZOFFSETFROM:-0700 TZOFFSETTO:-0800 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Los_Angeles:20190417T160000 DTEND;TZID=America/Los_Angeles:20190417T170000 LOCATION:JR Howard 116 SUMMARY:BCMB Seminar: Simran Handa '19 DESCRIPTION:Please join us for the BCMB seminar this Wednesday. Simran Ha nda '19 will be presenting her research. Date/time: April 17 at 4 pm (co me a little early for snacks!) Place: J. R. Howard 116Title: Investigati ng the putative GEF of a Rab GTPase in lysosome-related organelle biogene sis Abstract: Rab GTPases (Rabs) are proteins that are spatial and tempo ral regulators of organelle dynamics within cells. Rabs function in intra cellular transport and organelle biogenesis as molecular switches\, havin g two main conformations: a GTP-bound active form that can bind effectors \, and a GDP-bound inactive form that cannot. Guanine-exchange factors (G EFs) activate Rabs by catalyzing GDP to GTP exchange. I present genetic a nd biochemical data proposing a new GEF for GLO-1\, a Rab GTPase involved in lysosome-related organelle biogenesis in C. elegans. I found that the two subunits of the putative GEF complex—GLO-3 and CCZ-1—physically interact with each other and inactive GLO-1(GDP)\, pointing toward their role as a GEF. Related Paper: https://journals.plos.org/plosgenetics/art icle?id=10.1371/journal.pgen.1007772 X-ALT-DESC;FMTTYPE=text/html:
Please join us for the BCMB seminar thi s Wednesday. Simran Handa '19 will be presenting her research.
Da te/time: April 17 at 4 pm (come a little early for snacks!)
Place : J. R. Howard 116
Title: Investigating the putative GEF of a Rab GTPase in lysosome-related organelle biogenesis
A bstract: Rab GTPases (Rabs) are proteins that are spatial and temporal re gulators of organelle dynamics within cells. Rabs function in intracellul ar transport and organelle biogenesis as molecular switches\, having two main conformations: a GTP-bound active form that can bind effectors\, and a GDP-bound inactive form that cannot. Guanine-exchange factors (GEFs) a ctivate Rabs by catalyzing GDP to GTP exchange. I present genetic and bio chemical data proposing a new GEF for GLO-1\, a Rab GTPase involved in ly sosome-related organelle biogenesis in C. elegans. I found that the two subunits of the putative GEF complex—GLO-3 and CCZ-1—physical ly interact with each other and inactive GLO-1(GDP)\, pointing toward the ir role as a GEF.
Related Paper: https://journals.plos.org/plosge netics/article?id=10.1371/journal.pgen.1007772
UID:20190417T230000Z-303496@college.lclark.edu DTSTAMP:20190306T155205Z URL:https://college.lclark.edu/live/events/303496-bcmb-seminar-simran-han da-19 LAST-MODIFIED:20190410T230214Z X-LIVEWHALE-TYPE:events X-LIVEWHALE-ID:303496 X-LIVEWHALE-TIMEZONE:America/Los_Angeles X-LIVEWHALE-TAGS:BCMB seminar END:VEVENT END:VCALENDAR