BCMB Seminar: Alejandro Aballay, PhD
Date: 4:00pm PDT March 20 Location: JR Howard 116
JR Howard 116
Alejandro Aballay of OHSU will be giving a seminar on March 20, titled “Role of neuronal GPCR signaling in the control of response against bacterial infections and immune homeostasis.”
Please join us for snacks at 3:45 pm.
Alejandro Aballay’s lab has a broad research program encompassing genetics, functional genomics and neurobiological approaches to study mechanisms involved in the control of immune responses against microbial pathogens. Immune activation needs to be fine-tuned since deficient or excessive inflammation can lead to cancer or other conditions such as Crohn’s disease, rheumatoid arthritis, atherosclerosis, diabetes, and Alzheimer’s disease.
The Aballay Lab has demonstrated that specific neurons control innate immunity in the intestinal cells of the nematode Caenorhabditis elegans, in part by down-modulating a mitogen-activated protein kinase signaling pathway similar to the mammalian p38 MAPK pathway that is highly conserved across metazoans. The lab found that G-protein coupled receptors (GPCRs) participate in neural circuits that control conserved microbial-killing pathways and cellular homeostatic pathways that are expressed in non-neuronal tissues and that are necessary to alleviate the cellular stress that takes place during immune activation.